If your doctor has directed you to drink less fluid for other medical reasons, consult your doctor for further instructions. The dose of this medicine will be different for different patients. Limit alcoholic beverages. Visit your doctor regularly. Allopurinol is used to treat gout, high levels of uric acid in the body caused by certain cancer medications, and kidney stones. Kidney function declines as you grow older. Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease, kidney disease, diabetes, high blood pressure (hypertension), unusual diets (e.g., fasting). The following information includes only the average doses of this medicine. WebMD does not provide medical advice, diagnosis or treatment. It works well for preventing gout attacks, although it is not very effective for treating a gout attack that is already occurring (in fact, it can temporarily worsen gout, especially at first). Brand Name: Zyloprim, Lopurin, Aloprim. You should not take allopurinol if you are allergic to it. Allopurinol is used to prevent or lower high uric acid levels in the blood. This survey is being conducted by the WebMD marketing sciences department. It is also used to prevent increased uric acid levels in patients receiving cancer chemotherapy. Select one or more newsletters to continue. Allopurinol should also be used with caution in certain patients with hyperuricemia. Consult your doctor for more details. Brand names: Zyloprim and Lopurin. Learn from their experiences about effectiveness, side effects and cost Zyloprim is the brand name of this medicine. Each scored white tablet contains 100 mg allopurinol and the inactive ingredients lactose, magnesium stearate, potato starch, and povidone. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use allopurinol only for the indication prescribed. Your doctor may recommend other gout medication to take at this time. Allopurinol drug interactions (in more detail). Allopurinol [4–hydroxypyrazolo (3,4–d) pyrimidine] is an inhibitor of xanthine oxidase, the enzyme responsible for the conversion of hypoxanthine and xanthine to uric acid. Take this medication after a meal to reduce stomach upset. However, you may not be able to tell it apart from a rare rash that could be a sign of a severe reaction. You should not use allopurinol if you have ever had a serious allergic reaction to it. Breastfed infants of mothers receiving allopurinol should be monitored for signs of allopurinol side effects, such as rash. This is not a complete list of possible side effects. Tell your doctor right away if any of these rare but very serious side effects occur: numbness/tingling of arms/legs, easy bleeding/bruising, unusual tiredness, signs of kidney problems (such as change in the amount of urine, painful/bloody urination), yellowing eyes/skin, severe stomach/abdominal pain, persistent nausea/vomiting, dark urine, unusual weight loss, eye pain, vision changes. Allopurinol is a drug used primarily to treat hyperuricemia and its complications, including chronic gout.It is a xanthine oxidase inhibitor which is administered orally. It is best to drink a full glass of water with each dose and at least 8 more glasses (8 ounces each) of fluid a day. Allopurinol dosage information (in more detail). Allopurinol is a xanthine oxidase inhibitor that works by decreasing the uric acid produced by the body. Many people using this medication do not have serious side effects. Do not store in the bathroom. Allopurinol is likely safe in breast feeding although human data is limited. copyrighted by First Databank, Inc. USES: Allopurinol is used to treat gout and certain types of kidney stones. Follow all directions on your prescription label and read all medication guides or instruction sheets. Stomach upset, nausea, diarrhea, or drowsiness may occur. It is also used to prevent increased uric acid levels in patients receiving cancer chemotherapy. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. ZYLOPRIM (allopurinol) is known chemically as 1,5-dihydro-4H-pyrazolo [3,4-d]pyrimidin-4-one.It is a xanthine oxidase inhibitor which is administered orally. uses, directions, precautions, drug interactions or You may report side effects to FDA at 1-800-FDA-1088. Do not start, stop, or change the dosage of any medicines without your doctor's approval. In Canada - Call your doctor for medical advice about side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. be authorized by the applicable terms of use. You may need to follow a special diet while using allopurinol. A healthcare professional However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: fever, swollen lymph nodes, rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing. Not all possible drug interactions are listed here. Tell your doctor if you are pregnant or plan to become pregnant. US residents can call their local poison control center at 1-800-222-1222. material has been downloaded from a licensed data provider and is not for distribution, except as may The long-term management of gout, to control uric acid levels and prevent gout attacks. It can make your condition worse. More frequently reported side effects include: acute gout attack. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment. Talk to your pharmacist for more details. Do not double the dose to catch up. To make sure allopurinol is safe for you, tell your doctor if you have ever had: It is not known whether this medicine will harm an unborn baby. Discuss the risks and benefits with your doctor. Take allopurinol exactly as prescribed by your doctor. Does Allopurinol interact with other medications? Allopurinol is considered by the American Academy of Pediatrics to be compatible with breastfeeding. It is also sometimes used to treat a rare disease of purine metabolism in children. Dosage is based on your medical condition and response to treatment. Allopurinol is approved for treating gout. Some products that may interact with this drug are: "blood thinners" (e.g., warfarin), capecitabine, didanosine. Should I avoid certain foods while taking Allopurinol? We comply with the HONcode standard for trustworthy health information -, Calcium Oxalate Calculi with Hyperuricosuria. Allopurinol does pass into breast milk. Canada residents can call a provincial poison control center. You may have more gout attacks for several months after starting this medicine while the body removes extra uric acid. Get medical help right away if you develop any rash. Allopurinol is an inhibitor of xanthine oxidase, a substance in the body that is responsible for the product of uric acid. In order to explain its potential clinical benefits, it is best to first review its pharmacology and clinical pharmacology. A very serious allergic reaction to this drug is rare. an increase in uric acid due to cancer chemotherapy, recurrent calcium-containing kidney stones, prevention of calcium-containing kidney stones. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Take your next dose at the regular time. Allopurinol is approved for treating high uric acid levels in children with cancer. High levels of uric acid may cause gout attacks or kidney stones. Increased uric acid levels can cause gout and kidney problems. It is taken by mouth or injected into a vein. It is also used to prevent increased uric acid levels in patients receiving chemotherapy.These patients can have increased uric acid levels due to the release of uric acid from the dying cancer cells. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. If you are taking allopurinol to treat kidney stones, you may benefit from a special diet. Selected from data included with permission and This list is not complete. Alcohol or marijuana (cannabis) can make you more drowsy. These patients can have increased uric acid levels due to release of uric acid from the dying cancer cells. Allopurinol may impair your thinking or reactions. Find information about which conditions allopurinol oral is commonly used to treat. Other drugs may interact with allopurinol, including prescription and over-the-counter medicines, vitamins, and herbal products. This medication can commonly cause a rash that is usually not serious. You may report side effects to Health Canada at 1-866-234-2345. For the treatment of gout, it may take up to several weeks for this medicine to have an effect. Common allopurinol side effects may include: This is not a complete list of side effects and others may occur. Consult your doctor before breast-feeding. Allopurinol should be used in pregnancy only if clearly instructed by the doctor and it should be used with caution by breast feeding women. Allopurinol is a prescription medication used to treat gout and certain types of kidney stones. The information is not intended to cover all possible This document does not contain all possible drug interactions. Moderate side effects This lesson will discuss the dosage, withdrawal symptoms, and toxicity of allopurinol. Uric acid buildup can lead to gout or kidney stones. Allopurinol is the most common pharmaceutical used to manage gout and it has been approved for use in the USA since 1966. Allopurinol reduces the production of uric acid in your body. Allopurinol is used to treat gout and certain types of kidney stones. Laboratory and/or medical tests (e.g., uric acid blood levels, liver/kidney function tests, complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details. Version: 6.02. sodium bicarbonate, Zyloprim, febuxostat, Uloric, probenecid, Elitek, Krystexxa, Zurampic, Aloprim. In veterinary medicine, this is a drug which is used in combination with drugs such as miltefosine which is administered to treat leishmaniasis. Allopurinol (al-oh-pure-ri-nol) is mainly used for the long-term treatment and prevention of gout. What should I know regarding pregnancy, nursing and administering Allopurinol to children or the elderly? It is specifically used to prevent gout, prevent specific types of kidney stones and for the high uric acid levels that can occur with chemotherapy. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment. To reduce your risk of kidney stones forming, drink 8 to 10 full glasses of fluid every day, unless your doctor tells you otherwise. Store at room temperature away from light and moisture. Allopurinol, sold under the brand name Zyloprim among others, is a medication used to decrease high blood uric acid levels. Take this medication by mouth, usually once daily or as directed by your doctor. It may not be safe to breast-feed while using this medicine. Allopurinol is a medication used to treat gout. It works by reducing the production of uric acid in the body. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Alcohol may also decrease the effectiveness of this drug. Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Avoid drinking alcohol. Uric acid buildup can lead to gout or kidney stones.. Allopurinol is used to treat gout or kidney stones, and to decrease levels of uric acid in people who are receiving cancer treatment.. Allopurinol may also be used for purposes not listed in this medication guide. Allopurinol works by reducing the amount of uric acid made by the body. Your reactions could be impaired. is intended to supplement, not substitute for, the Available for Android and iOS devices. Use a reduced dose in elderly people and in those with hepatic impairment: Prescribe an allopurinol starting dose of 50 mg once a day (allopurinol 50 mg tablets are not available, so when providing a 50 mg dose check that the 100 mg tablets are scored). What is allopurinol used for? During pregnancy, this medication should be used only when clearly needed. Allopurinol has also been shown to decrease oxidative stress and ameliorate the morbidity and mortality of congestive heart failure patients by possibly improving mechanoenergetic uncoupling, with the enhancement of myocardial contractility and the left ventricular ejection fraction. Allopurinol is not a pain reliever. This medication is removed by the kidneys. Allopurinol works by reducing the amount of uric acid made by the body. 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